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The limited success of iron chelators used in neurological disorders has led to the exploration of optimized drug delivery systems that can overcome these barriers (Meade, 1975)

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Together with other proteasomal subunits including RPN10, RPN8, and RPT4/5, a multivalent recognition groove tailored for K11-linked Ub chains is formed, potentially leading to higher affinity and specificity, thereby enhancing substrate recognition and accelerating degradation